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Breaking up is hard to do
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kashatus, David F. Counter, Christopher M. |
| Copyright Year | 2011 |
| Abstract | The small GTPases RalA and RalB are activated downstream of oncogenic Ras. While activation of RalA is critically important for tumor initiation and growth of Ras-driven cancers, the highly similar small GTPase RalB is implicated in cell survival and metastasis. This difference in function between these two related proteins maps to the C-terminus, a 30 amino acid region that regulates subcellular localization and contains several potential phosphorylation sites. Here we discuss our recent evidence that phosphorylation by the mitotic kinase Aurora A promotes RalA relocalization to mitochondrial membranes, where it recruits the effector RalBP1 and the large dynamin-related GTPase Drp1 to promote mitochondrial fission. As upregulation of both RalA and Aurora A have been observed in human tumors, and phosphorylation of RalA at the site targeted by Aurora A promotes tumorigenesis, it is possible that regulation of mitochondrial fission is one mechanism by which RalA promotes cancer. |
| Starting Page | 329 |
| Ending Page | 333 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1126/science.304.5667.13a |
| Alternate Webpage(s) | http://www.princetoninsurance.com/downloads/Risk_Review_Downloads/8.2012/RRO_Aug2012_BreakingUp.pdf |
| Alternate Webpage(s) | https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c7/11/sgtp-2-329.PMC3337163.pdf |
| Alternate Webpage(s) | http://el.media.mit.edu/logo-foundation/resources/nlx/v2/Vol2No8.pdf |
| PubMed reference number | 22545232 |
| Alternate Webpage(s) | https://doi.org/10.1126/science.304.5667.13a |
| Journal | Medline |
| Volume Number | 2 |
| Journal | Small GTPases |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
