NDLI: Prostate cancer downregulated SIRP-α modulates apoptosis and proliferation through p38-MAPK/NF-κB/COX-2 signaling.

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Prostate cancer downregulated SIRP-α modulates apoptosis and proliferation through p38-MAPK/NF-κB/COX-2 signaling.

Content Provider	Semantic Scholar
Author	Yao, Chen Li, Gang Cai, Ming Qian, Yeyong Wang, Liqin Xiao, Li Thaiss, Friedrich Shi, Bingyi
Copyright Year	2017
Abstract	The present study investigated the regulatory mechanism of signal-regulatory protein (SIRP)-α in the apoptosis and proliferation of prostate cancer (CaP) cells. The expression profile of SIRP-α in prostate cancer cells was analyzed using reverse transcription-quantitative polymerase chain reaction and western blotting. Then SIRP-α function in CaP cells was further analyzed with the overexpression and RNA interference of SIRP-α. The results revealed that SIRP-α expression levels were decreased in CaP tissues and cell lines, with androgen-independent CaP exhibiting a lower SIRP-α expression compared with androgen-dependent CaP. Overexpression of SIRP-α resulted in a significantly reduced number of live CaP cells by enhancing apoptosis, whereas SIRP-α silencing increased CaP cell proliferation. Mechanistically, SIRP-α decreases cyclooxygenase-2 (COX-2) expression and cytokine production by negatively regulating p38 mitogen-activated protein kinase and nuclear factor-κB pathway. Therefore, SIRP-α knockdown decreases cell apoptosis by enhancing COX-2 expression. The present results indicate that SIRP-α may function as a novel negative regulator to modulate cellular proliferation, survival and migration in CaP cells. The heightened sensitivity of cells restoring SIRP-α function could be exploited in the development of therapeutics that may potentiate the antineoplastic effects of conventional cytokines or chemotherapeutic agents.
Starting Page	4995
Ending Page	5001
Page Count	7
File Format	PDF HTM / HTML
DOI	10.3892/ol.2017.6070
PubMed reference number	28588738
Journal	Medline
Volume Number	13
Issue Number	6
Journal	Oncology letters
Alternate Webpage(s)	https://tessera.spandidos-publications.com/ol/13/6/4995/download
Alternate Webpage(s)	https://doi.org/10.3892/ol.2017.6070
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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