NDLI: Evidence by reactivity with hybridoma antibodies for a probable myeloid origin of peripheral blood cells active in natural cytotoxicity and antibody-dependent cell-mediated cytotoxicity.

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Evidence by reactivity with hybridoma antibodies for a probable myeloid origin of peripheral blood cells active in natural cytotoxicity and antibody-dependent cell-mediated cytotoxicity.

Content Provider	Semantic Scholar
Author	Horwitz, David Allen
Copyright Year	1980
Abstract	Lymphocytes with Fc receptors (FcR) for IgG active in natural cytotoxicity and antibody-dependent cellular cytotoxicity were separated into sheep erythrocyte rosetting (E+) and nonrosetting (E-) fractions, and examined for reactivity with the OK panel of hybridoma-produced monoclonal antibodies. Few cells in either the E+ FcR+ or the E- FcR+ fraction reacted with seven antibodies used to define T cells in various stages of differentiation (OK3, OKT4, OKT5, OKT6, OKT8, OKT9, OKT10). Neither fraction expressed an Ia-like antigen (detected by OKI1), but both were highly reactive with OKM1, an antibody that reacts with monocytes and granulocytes. Incubation of these cytotoxic effector cells with OKM1 plus complement abolished all cytotoxic reactivity, but incubation with a pan-T cell antibody (OKT3) plus complement had no significant effect. These cells were not monocyte precursors, because they could not be induced in vitro to develop macrophage characteristics. The data indicate that most cytotoxic effector cells in natural cytotoxicity and antibody-dependent cellular cytotoxicity are not in the T cell lineage, but have a myeloid origin.
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Alternate Webpage(s)	https://dm5migu4zj3pb.cloudfront.net/manuscripts/109000/109923/cache/109923.1-20140626150517-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf
Alternate Webpage(s)	http://dm5migu4zj3pb.cloudfront.net/manuscripts/109000/109923/JCI80109923.pdf
PubMed reference number	6968324v1
Volume Number	66
Issue Number	4
Journal	The Journal of clinical investigation
Language	English
Access Restriction	Open
Subject Keyword	Antibody-Dependent Cellular Cytotoxicity Cell-Mediated Cytolysis Complement System Proteins Eryptosis Erythrocytes Fc Receptor Granulocyte count Hybridomas Leukemia, B-Cell Muromonab-CD3 Probability T-Lymphocyte modulation by symbiont of host erythrocyte aggregation peripheral blood
Content Type	Text
Resource Type	Article

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