Loading...
Please wait, while we are loading the content...
Similar Documents
Effect of (1–24)adrenocorticotrophin on the uptake of 3H-norepinephrine by the rat atria
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mehrabani, P. A. Bassett, Jack R. |
| Copyright Year | 1988 |
| Abstract | Spontaneously beating rat atria were incubated with 3H-norepinephrine both in the presence and absence of (1-24)ACTH. A significant reduction in the uptake and retention of radioactivity was found in atria pretreated with (1-24)ACTH. A kinetic study of the uptake process showed similar Km values for both the control (24.1 x 10(-8) M) and (1-24)ACTH pretreated (22.2 x 10(-8) M) groups, but a significantly different Vmax. The Km values were similar to that reported for the neuronal reuptake process (Uptake 1). It was concluded that the ACTH-induced enhanced myocardial sensitivity to catecholamines previously reported, could be explained in part on the basis of an inhibition of neuronal uptake by (1-24)ACTH. The inhibition of neuronal uptake by (1-24)ACTH was dose-dependent. |
| Starting Page | 391 |
| Ending Page | 396 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0091-3057(88)90473-X |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/009130578890473X |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/009130578890473X?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 2845444 |
| Alternate Webpage(s) | https://doi.org/10.1016/0091-3057%2888%2990473-X |
| Journal | Medline |
| Volume Number | 30 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
