NDLI: S8-1. Principle of Time-Resolved Spectroscopy for quantitative tissue oxygenation monitoring

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S8-1. Principle of Time-Resolved Spectroscopy for quantitative tissue oxygenation monitoring

Content Provider	Semantic Scholar
Author	Yamashita, Yutaka
Copyright Year	2013
Abstract	In Time-Resolved Spectroscopy (TRS), a temporal response of scattered light is measured after irradiation of ultra-short pulses, thereby giving a path-length distribution of detected photons traveling in the living tissue. Applying the photon diffusion theory into this response allows determination of the transport scattering coefficient and the absorption coefficient of the tissue. On the assumption that the absorption in the 700–900 nm range arises from the HbO 2 , Hb and water, it is possible to quantitate the hemoglobin concentration by multispectral measurement. Our two-channel TRS system (TRS-20) carries a three-wave length (780, 800, 830 nm) picosecond light pulser and enables us to quantitate the hemoglobin concentration of the tissue. When it was used as a cerebral hemodynamics monitor in a coronary artery bypass grafting, we found a good correlation ( r 2 = 0.64) between the hemoglobin concentration obtained by TRS-20 and hematocrit value of arterial blood, reflecting blood dilution correctly during the operation. In addition, the trend of tissue oxygen saturation measured by TRS-20 was well consistent with the internal jugular vein oxygen saturation. These results demonstrated the usefulness of TRS as a quantitative monitor of cerebral hemodynamics.
File Format	PDF HTM / HTML
DOI	10.1016/j.clinph.2013.02.041
Volume Number	124
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S1388245713001430
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S1388245713001430?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.clinph.2013.02.041
Journal	Clinical Neurophysiology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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