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Second Harmonic Generation Guided Raman Spectroscopy for Sensitive Detection of Polymorph Transitions.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chowdhury, Azhad U. Ye, Dong Hye Song, Zhengtian Zhang, Shijie Hedderich, Hartmut G. Mallick, Babita Thirunahari, Satyanarayana Srividya Ramakrishnan Sengupta, Atanu Gualtieri, Ellen J. Bouman, Charles A. Simpson, Garth J. |
| Copyright Year | 2017 |
| Abstract | Second harmonic generation (SHG) was integrated with Raman spectroscopy for the analysis of pharmaceutical materials. Particulate formulations of clopidogrel bisulfate were prepared in two crystal forms (Form I and Form II). Image analysis approaches enable automated identification of particles by bright field imaging, followed by classification by SHG. Quantitative SHG microscopy enabled discrimination of crystal form on a per particle basis with 99.95% confidence in a total measurement time of ∼10 ms per particle. Complementary measurements by Raman and synchrotron XRD are in excellent agreement with the classifications made by SHG, with measurement times of ∼1 min and several seconds per particle, respectively. Coupling these capabilities with at-line monitoring may enable real-time feedback for reaction monitoring during pharmaceutical production to favor the more bioavailable but metastable Form I with limits of detection in the ppm regime. |
| Starting Page | 5958 |
| Ending Page | 5965 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://engineering.purdue.edu/~bouman/publications/orig-pdf/analy-chem-2017.pdf |
| PubMed reference number | 28481538v1 |
| Alternate Webpage(s) | https://doi.org/10.1021/acs.analchem.7b00431 |
| DOI | 10.1021/acs.analchem.7b00431 |
| Journal | Analytical chemistry |
| Volume Number | 89 |
| Issue Number | 11 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antidepressive Agents, Second-Generation Classification Clopidogrel bisulfate Spectroscopy, Near-Infrared Synchrotrons neutrophil part per million (ppm) |
| Content Type | Text |
| Resource Type | Article |
