from mycobacteria and Escherichia coli : mechanism of urad ! excision from synthetic substrates and differential interaction with uracil DNA glycosy ~ lase inhibitor ( Ugi ) and single stranded DNA binding proteins ( SSBs )

Content Provider	Semantic Scholar
Author	Varshney, Umesh
Copyright Year	2013
Abstract	Mycobacteria are responsible for a variety of public health problems. According to recent WHO reports, about 3 million people die every year due to tuberculosis making it the most serious pathogen of the human race. Further, the emergence of multidrug resistant strains has made it imperative to understand the biology of these organisms. Mycobacteria multiply inside the host macrophages where they are subjected to oxidative and other kinds of physiological stresses. Such adverse conditions result in various DNA damages. However, the mechanisms of DNA repair in these organisms have not been studied in detail. (A brief review of current research on mycobacteria, DNA damage and repair in prokaryotes along with DNA repair genes in M. tuberculosis is given in Chapter 1 of the thesis).
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://journal.iisc.ernet.in/index.php/iisc/article/download/787/811
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article