NDLI: Cessation of spermatogenesis in juvenile spermatogonial depletion (jsd/jsd) mice.

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Cessation of spermatogenesis in juvenile spermatogonial depletion (jsd/jsd) mice.

Content Provider	Semantic Scholar
Author	Kojima, Yoshiyuki Kominami, Katsuya Dohmae, Kayoko Nonomura, Norio Miki, Tsuneharu Okuyama, Akihiko Nishimune, Yoshitake Okabe, Motonori
Copyright Year	1997
Abstract	BACKGROUND Mice homozygous for the jsd (juvenile spermatogonial depletion) allele are sterile because they become azoospermic. The onset of such azoospermia was investigated by histologic analysis of sections of testes from jsd/jsd mice. METHOD The testes removed from C57BL/6-jsd/jsd mice aged 3 to 10 weeks were examined microscopically. RESULTS At 3 weeks of age, spermatocytes were seen in most of the seminiferous tubules of jsd/jsd mice. However, the number of tubules that contained spermatids was significantly smaller than that counted in the wild-type mice. Since degenerative figures were not abundant in the jsd/jsd testes, the decreased number of spermatids found in the tubules suggested a longer duration of development from spermatocyte to spermatid in jsd/jsd mice. The abnormality extended to the development of type B spermatogonia, and a decrease in their number became apparent after 6 weeks of age in most of the jsd/jsd tubules. However, as early as 3 weeks of age, a few seminiferous tubules in jsd/jsd mice already contained only Sertoli cells and type A spermatogonia. CONCLUSION It is assumed that the decrease in type B spermatogonia occurred at various ages and locations. The defect of spermatogenesis in jsd/jsd mice was attributable to aberrations in multiple steps of spermatogenesis.
File Format	PDF HTM / HTML
DOI	10.1111/j.1442-2042.1997.tb00293.x
Alternate Webpage(s)	https://ir.library.osaka-u.ac.jp/repo/ouka/all/41052/13578_%E8%A6%81%E6%97%A8.pdf
PubMed reference number	9354954
Alternate Webpage(s)	https://doi.org/10.1111/j.1442-2042.1997.tb00293.x
Journal	Medline
Volume Number	4
Issue Number	5
Journal	International journal of urology : official journal of the Japanese Urological Association
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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