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Influencia de la grasa de la dieta en el metabolismo glucídico de mujeres obesas con el genotipo Pro12Pro en el gen PPARgama2
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kaippert, Vanessa Chaia Rosado, Eliane Lopes Rosa, Glorimar Oliveira, E. M. Uehara, Sofia Kimi D'Andrea, Cosimo Nogueira, Juliana H. C. Lago, Márcia Fófano Do |
| Copyright Year | 2010 |
| Abstract | Introduction: The peroxisome proliferator-activated receptor gamma 2 (PPARγ2) is an adipogenic transcrip- tion factor that influences in insulin resistance (IR) in the presence of agonists such as polyunsaturated fatty acids (PUFA). Objective: Evaluate the influence of dietary fat in glicidic metabolism in morbidly obese women with Pro12Pro geno- type in the gene PPARγ2. Methods: Were selected 25 women with genotype Pro12Pro. The fat intake was estimated by food records, being used for the division of groups, GA (until 30% of the total energy expenditure (TEE)) and GB (greater than 30% of the TEE). Biochemical and anthropometric evaluations were conducted in fasting, following the test meal high in n-6 PUFA and postprandial biochemical evaluations. IR and insulin sensitivity (IS) were assessed by HOMA-IR (Homeostasis Model Assessment) and QUICKI (Quantitative Insulin Sensitivity Check Index), respectively. Results and discussion: GA presented normal HOMA- IR and QUICKI. GB presented higher body mass index (BMI), HOMA-IR, saturated fatty acids (SFA) and monounsaturated (MUFA) intake higher, compared with GA (p < 0.05). In GA, the MUFA intake was negatively correlated with HOMA-IR, fasting glucose and insulin, and positively with QUICKI. The fat and SFA intake con- tributed to the increase in body mass and IR. However, MUFA intake may have reduced the impact of high fat diet in glicidic metabolism. It is suggested that obese women with Pro12Pro genotype in the PPARγ2 gene avoid high fat and SFA diets, prioritizing MUFA for con- trolling obesity and improving the IS. |
| Starting Page | 622 |
| Ending Page | 629 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.3305/nh.2010.25.4.4468 |
| Volume Number | 25 |
| Alternate Webpage(s) | http://scielo.isciii.es/pdf/nh/v25n4/original10.pdf |
| Alternate Webpage(s) | http://www.redalyc.org/pdf/3092/309226761014.pdf |
| Alternate Webpage(s) | https://doi.org/10.3305/nh.2010.25.4.4468 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
