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Small-conductance Ca2+-activated K+ channels modulate action potential-induced Ca2+ transients in hippocampal neurons.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tonini, Raffaella Ferraro, Teresa Sampedro-Castañeda, Marisol Cavaccini, Anna Stocker, Martin Richards, Christopher D. Pedarzani, Paola |
| Copyright Year | 2013 |
| Abstract | In hippocampal pyramidal neurons, voltage-gated Ca(2+) channels open in response to action potentials. This results in elevations in the intracellular concentration of Ca(2+) that are maximal in the proximal apical dendrites and decrease rapidly with distance from the soma. The control of these action potential-evoked Ca(2+) elevations is critical for the regulation of hippocampal neuronal activity. As part of Ca(2+) signaling microdomains, small-conductance Ca(2+)-activated K(+) (SK) channels have been shown to modulate the amplitude and duration of intracellular Ca(2+) signals by feedback regulation of synaptically activated Ca(2+) sources in small distal dendrites and dendritic spines, thus affecting synaptic plasticity in the hippocampus. In this study, we investigated the effect of the activation of SK channels on Ca(2+) transients specifically induced by action potentials in the proximal processes of hippocampal pyramidal neurons. Our results, obtained by using selective SK channel blockers and enhancers, show that SK channels act in a feedback loop, in which their activation by Ca(2+) entering mainly through L-type voltage-gated Ca(2+) channels leads to a reduction in the subsequent dendritic influx of Ca(2+). This underscores a new role of SK channels in the proximal apical dendrite of hippocampal pyramidal neurons. |
| File Format | PDF HTM / HTML |
| DOI | 10.1152/jn.00346.2012 |
| PubMed reference number | 23255726 |
| Journal | Medline |
| Volume Number | 109 |
| Issue Number | 6 |
| Alternate Webpage(s) | http://jn.physiology.org/content/jn/109/6/1514.full.pdf |
| Alternate Webpage(s) | http://jn.physiology.org/content/jn/early/2012/12/12/jn.00346.2012.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1152/jn.00346.2012 |
| Journal | Journal of neurophysiology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
