NDLI: In-vitro detection of thrombotic formation on bileaflet mechanical heart valves.

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In-vitro detection of thrombotic formation on bileaflet mechanical heart valves.

Content Provider	Semantic Scholar
Author	Susin, Francesca Maria Tarzia, Vincenzo Bottio, Tomaso Pengo, Vittorio Bagno, Andrea Gerosa, Gino
Copyright Year	2011
Abstract	BACKGROUND AND AIM OF THE STUDY As with all mechanical prostheses, bileaflet heart valves are prone to thrombus formation, reduced hemodynamic performance, and the occurrence of embolic events. The early detection of thrombotic formations is crucial for correct diagnosis and adequate therapy. The study aim was to analyze the power spectra of the phonocardiographic signals acquired in vitro for various thrombotic deposits reproduced on a bileaflet mechanical valve, in order to monitor and classify their presence. METHODS Data were acquired for the St. Jude Medical Regent valve mounted in the aortic position of a Sheffield Pulse Duplicator. Different pulsatile flow conditions were reproduced, changing the heart rate and stroke volume. Thrombotic deposits of various weights and shapes were placed on the valve leaflet, or on the annular housing. The case of a thrombus completely blocking one leaflet was also investigated. Power spectra were calculated from the phono-cardiographic signals and classified by an artificial neural network. RESULTS The proposed approach resulted in a 95% correct identification of all simulated thrombotic deposits. Interestingly, phonocardiographic analysis is capable of detecting the presence of different types of artificial thrombi and also to classify them, whereas transvalvular pressure values cannot provide such detection. CONCLUSION An effective diagnostic tool capable of detecting valvular thrombosis at the early stages of formation may help clinicians to formulate valvular dysfunction diagnoses before the appearance of critical symptoms. The ability to transfer results obtained in vitro to actual clinical situations might represent a significant advance in the follow up of patients.
File Format	PDF HTM / HTML
PubMed reference number	21863649
Journal	Medline
Volume Number	20
Issue Number	4
Alternate Webpage(s)	https://www.researchgate.net/profile/Tomaso_Bottio/publication/51592197_In-vitro_detection_of_thrombotic_formation_on_bileaflet_mechanical_heart_valves/links/0912f50bf47d0e0121000000.pdf
Journal	The Journal of heart valve disease
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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