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Transcriptional inhibition of genes with severe histone h3 hypoacetylation in the coding region.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kristjuhan, Arnold Walker, J. Suka, Noriyuki Roberts, Douglas Svejstrup, Jesper Qualmann |
| Copyright Year | 2002 |
| Abstract | Changes in histone acetylation at promoters correlate with transcriptional activation and repression, but whether acetylation of histones in the coding region of genes is important for transcription is less clear. Here, we show that cells lacking the histone acetyltransferases Gcn5 and Elp3 have widespread and severe histone H3 hypoacetylation in chromatin. Surprisingly, severe hypoacetylation in the promoter does not invariably affect the ability of TBP to bind the TATA element, or transcription of the gene. By contrast, similar hypoacetylation of the coding region correlates with inhibition of transcription, and inhibition correlates better with the overall charge of the histone H3 tail than with hypoacetylation of specific lysine residues. These data provide insights into the effects of histone H3 hypoacetylation in vivo and underscore the importance of the overall charge of the histone tail for transcription. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.hci.utah.edu/publicweb/content/cairns/pdf/Kristjuhan_A.pdf |
| PubMed reference number | 12419235v1 |
| Volume Number | 10 |
| Issue Number | 4 |
| Journal | Molecular cell |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | ELP3 gene Histone Acetylation Histone H3 Histones Lysine Open Reading Frames Protein Acetylation Repression, Psychology TBP gene Transcription, Genetic Transcriptional Activation histone acetyltransferase promoter |
| Content Type | Text |
| Resource Type | Article |
