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Glycine antagonists block the induction of long-term potentiation in CA1 of rat hippocampal slices
| Content Provider | Semantic Scholar |
|---|---|
| Author | Izumi, Yukitoshi Clifford, David B. Zorumski, Charles F. |
| Copyright Year | 1990 |
| Abstract | The effects of the strychnine-insensitive glycine receptor antagonists, cycloleucine and 7-chlorokynurenic acid, on the induction of long-term potentiation (LTP) in CA1 of rat hippocampal slices were examined. A 5 min administration of cycloleucine (20-100 microM) or 7-chlorokynurenic acid (1-5 microM) during the delivery of high-frequency stimulation blocked the induction of LTP without affecting baseline synaptic transmission. Coapplication of 100 microM glycine with cycloleucine or 7-chlorokynurenic acid masked the inhibitory effect on the induction of LTP, supporting the hypothesis that these compounds act as glycine antagonists. These results indicate that glycine is a necessary factor for the induction of LTP in CA1 of the rat hippocampus. |
| Starting Page | 251 |
| Ending Page | 256 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(90)90212-R |
| PubMed reference number | 2359524 |
| Journal | Medline |
| Volume Number | 112 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/030439409090212R |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/030439409090212R?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2890%2990212-R |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
