NDLI: Phr1 is required for proper retinocollicular targeting of nasal-dorsal retinal ganglion cells.

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Phr1 is required for proper retinocollicular targeting of nasal-dorsal retinal ganglion cells.

Content Provider	Semantic Scholar
Author	Vo, Bradly Q. Bloom, A. Joseph Culican, Susan M.
Copyright Year	2011
Abstract	Precise targeting of retinal projections is required for the normal development of topographic maps in the mammalian primary visual system. During development, retinal axons project to and occupy topographically appropriate positions in the dorsal lateral geniculate nucleus (dLGN) and superior colliculus (SC). Phr1 retinal mutant mice, which display mislocalization of the ipsilateral retinogeniculate projection independent of activity and ephrin-A signaling, were found to have a more global disruption of topographic specificity of retinofugal inputs. The retinocollicular projection lacks local refinement of terminal zones and multiple ectopic termination zones originate from the dorsal-nasal (DN) retinal quadrant. Similarly, in the dLGN, the inputs originating from the contralateral DN retina are poorly refined in the Phr1 mutant. These results show that Phr1 is an essential regulator of retinal ganglion cell projection during both dLGN and SC topographic map development.
Starting Page	362
Ending Page	366
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=4323&context=open_access_pubs
Alternate Webpage(s)	https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=4323&context=open_access_pubs
PubMed reference number	21324225v1
Alternate Webpage(s)	https://doi.org/10.1017/S0952523810000386
DOI	10.1017/s0952523810000386
Journal	Visual neuroscience
Volume Number	28
Issue Number	2
Language	English
Access Restriction	Open
Subject Keyword	Axon Cell Nucleus Corpora quadrigemina, superior colliculus Ectopic Graft Ephrin-A Ephrins Ganglion cell Geniculate body structure Oxymetazoline hydrochloride 0.5 MG/ML Nasal Spray PLEKHB1 gene Projections and Predictions Retina Retinal Ganglion Cells cell projection cellular targeting lateral geniculate complex lateral geniculate nucleus
Content Type	Text
Resource Type	Article

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Phr1 is required for proper retinocollicular targeting of nasal-dorsal retinal ganglion cells.

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Phr1 is required for proper retinocollicular targeting of nasal-dorsal retinal ganglion cells.

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Phr1 is required for proper retinocollicular targeting of nasal-dorsal retinal ganglion cells.

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Phr1 is required for proper retinocollicular targeting of nasal-dorsal retinal ganglion cells.