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Michael R. Rose & Robert C. Griggs. Channelopathies of the nervous system. Butterworth-Heinemann, Boston, 2001. ISBN 0-7506-4507-5, 347 pp. $95
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rijckevorsel, Kenou Van |
| Copyright Year | 2002 |
| Abstract | This multiauthor book consists of 23 chapters shared out between 9 parts. It collects an impressive amount of data about channel function and disorders. The first, more “technical” part explains the physiology, molecular biology, and pharmacology of ion channels, the latter representing the first link with clinical application. The second, shorter, part describes the ways to explore ions channels in vivo and in vitro. These first two parts are very interesting for scientists and quite accessible for clinicians, thereby helping them better understand the pathophysiology of some syndromes and the mode of action of drugs. The third part is devoted to the plasticity of channel gene expression and its role in such clinical syndromes as neuropathic pain and demyelinating diseases. This part is highly useful, not only for neurologists, but also for the anesthesiologists involved in the treatment of chronic pain disorders. Neuromuscular channel gene disorders are described in Parts 4 and 5. These can be of genetic origin (periodic paralyses, myotonic diseases), acquired (myasthenia gravis, Lambert Eaton syndrome, auto-immune neuromyotonia), or mixed (genetic predisposition and action of some external agent like malignant hyperthermia). The overlap between clinical signs and channel dysfunction in genetic and acquired syndromes is clearly explained, with a nice development of clinical signs, their relationship to channel dysfunction and their therapeutic approach. The CNS channel disorders are developed in Part 6, with emphasis on epilepsies and some abnormal movements (idiopathic paroxysmal dyskinesia, hyperekplexia). When available, loci and gene are described with references to animal models and therapeutic perspectives. A calcium channelopathic theory is hypothesized for migraine, with pathophysiologic and clinical arguments. Part 8 briefly considers possible channelopathies: some unsolved myotonic dystrophy or myopathic syndromes. This book represents a large and comprehensive overview of the growing field of channelopathies. One can find a very nice clinical approach of each syndrome: clinical symptoms explained by pathophysiology, tests needed to confirm the diagnosis, genetic diagnosis or hypothesis and, finally, the way to treat it according to the channel dysfunction. Thai is, this book brings together the physiology, genetics, clinical manifestations and therapeutic perspectives provided by this new approach of several syndromes characterized by ion channel dysfunction. It is useful and I recommend it for neuroscientists, neurologists, anesthesiologists, geneticists, pediatricians, and pharmacologists. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0987-7053(02)00300-3 |
| Volume Number | 32 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0987705302003003 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0987705302003003?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0987-7053%2802%2900300-3 |
| Journal | Neurophysiologie Clinique/Clinical Neurophysiology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
