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Effects of thyrotropin-releasing hormone, oxytocin and prolactin on thiopenthal-induced narcosis in rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Drago, Filippo Mauceri, Francesco Fidilio, M. Cavaliere, S. Foti, Francesca |
| Copyright Year | 1992 |
| Abstract | Neuropeptides that may induce behavioral activation--thyrotropin-releasing hormone (TRH), oxytocin (OXY), and prolactin (PRL)--were tested on thiopenthal-induced narcosis after IV administration in male rats. TRH caused a significant shortening of sleeping time at the doses of 3 and 5 mg/kg, but did not change this parameter at lower doses. Oxytocin was effective at all doses tested (200, 300, and 400 micrograms/kg). Prolactin also shortened sleeping time at the doses of 0.2 and 1 mg/kg administered IV, slightly increasing it at the dose of 5 mg/kg. These results indicate that various neuropeptides are capable of reducing the duration of thiopenthal-induced sleep in rats. |
| Starting Page | 781 |
| Ending Page | 783 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0361-9230(92)90260-5 |
| PubMed reference number | 1617461 |
| Journal | Medline |
| Volume Number | 28 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0361923092902605 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0361923092902605?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0361-9230%2892%2990260-5 |
| Journal | Brain Research Bulletin |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
