NDLI: Relationship between 5-HTTLPR polymorphism and post-stroke depression.

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Relationship between 5-HTTLPR polymorphism and post-stroke depression.

Content Provider	Semantic Scholar
Author	Guo, Weiyun Zhang, Zhigong Mu, Junlin Zhao, Linlin Yao, Zhijun Song, Jinggui
Copyright Year	2016
Abstract	Post-stroke depression (PSD) is a mental illness characterized by subjective feelings of depression, cognitive dysfunction, and decreased interest. The serotoninergic system is involved in the pathogenesis of depressive disorders and is regulated by the serotonin transporter gene. The serotonin transporter-linked polymorphic region (5-HTTLPR) has been examined as a factor associated with depression and other mental disorders. This study was performed to explore the relationship between 5-HTTLPR and PSD in a Han Chinese population. In total, 199 patients with PSD and 202 unrelated non-PSD patients were recruited from psychiatric hospitals. Depression was diagnosed using the Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition. Blood samples were collected from all patients for 5-HTTLPR genotyping. Genotype and allele frequencies were compared between the two groups. SS genotype frequency was significantly higher in the PSD group than in the non-PSD group. LL genotype frequency was significantly higher in the non-PSD group than in the PSD group (P < 0.01). This study describes a positive association between 5-HTTLPR and PSD in a Han Chinese population and provides genetic evidence to support the genetic susceptibility of PSD.
File Format	PDF HTM / HTML
DOI	10.4238/gmr.15017460
PubMed reference number	26909988
Journal	Medline
Volume Number	15
Issue Number	1
Alternate Webpage(s)	https://geneticsmr.com/sites/default/files/articles/year2016/vol15-1/pdf/gmr7460_abstract.pdf
Alternate Webpage(s)	http://www.funpecrp.com.br/gmr/year2016/vol15-1/pdf/gmr7460.pdf
Alternate Webpage(s)	https://doi.org/10.4238/gmr.15017460
Journal	Genetics and molecular research : GMR
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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