Cavo-portal transposition in rat: a new simple model

Content Provider	Semantic Scholar
Author	Domenico, Stefano Di Bovio, Giulio Gelli, Maximiliano Ravazzoni, Ferruccio Andorno, Enzo Cottalasso, Damiano Valente, U.
Copyright Year	2007
Abstract	BACKGROUND Liver transplantation in presence of diffuse portal vein thrombosis is possible by using caval blood as portal inflow, through cavo-portal transposition. However, clinical results are heterogeneous and experimental studies are needed, but similar hemodynamic conditions are difficult to obtain, especially in small animals. Herein we describe a new simple model of cavo-portal transposition in rat. METHODS Spontaneous porto-systemic shunts are induced by subcutaneous transposition of the spleen. The presence of porto-caval shunts through the spleen permits the interruption of the main portal vein without splanchnic hemodynamic consequences. Cavo-portal transposition is achieved by anastomosing the inferior vena cava and the main portal vein after division of the pancreatic-duodenal vein. RESULTS Selective angiography revealed total splanchnic blood diversion to the systemic venous circulation through the neoformed collaterals; macroscopical examination showed the absence of any signs of acute portal hypertension with normal liver and gut appearance. CONCLUSION This model of cavoportal transposition is simple, effective and it simulates the clinical hemodynamic condition since the porto-systemic shunts induced by splenic subcutaneous transposition correspond to the physiological inframesocolic collaterals during chronic portal thrombosis in man.
Starting Page	18
Ending Page	18
Page Count	1
File Format	PDF HTM / HTML
PubMed reference number	17705819
Volume Number	7
Journal	BMC surgery
Alternate Webpage(s)	https://www.biomedcentral.com/imedia/1084079612153535_manuscript.pdf
Alternate Webpage(s)	http://download-redirector.springer.com/redirect?contentType=pdf&ddsId=art:10.1186/1471-2482-7-18&originUrl=http://bmcsurg.biomedcentral.com/article/10.1186/1471-2482-7-18
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/b1/14/envhper00356-0021-color.PMC1522186.pdf
Language	English
Access Restriction	Open
Subject Keyword	Duodenum Genetic Heterogeneity Hypertension, Portal Hypertensive disease Inferior vena cava structure License Liver diseases Main portal venous trunk Portal vein structure Portal vein thrombosis Spleen Tissue Structure of vein of trunk Superior Vena Cava Syndrome Venous Thrombosis angiogram hemodynamics (procedure)
Content Type	Text
Resource Type	Article