NDLI: Moderate alcohol consumption induces sustained cardiac protection by activating PKC-and Akt

Please wait, while we are loading the content...

Moderate alcohol consumption induces sustained cardiac protection by activating PKC-and Akt

Content Provider	Semantic Scholar
Author	Zhou, Hui-Zhong Gray, Mary O.
Copyright Year	2002
Abstract	Zhou, Hui-Zhong, Joel S. Karliner, and Mary O. Gray. Moderate alcohol consumption induces sustained cardiac protection by activating PKCand Akt. Am J Physiol Heart Circ Physiol 283: H165–H174, 2002. First published February 28, 2002; 10.1152/ajpheart.00408.2001.—C57BL/6 mice were fed 18% ethanol (vol/vol) in drinking water for 12 wk. Isovolumic hearts were subjected to 20 min of ischemia and 30 min of reperfusion on a Langendorff apparatus. There were no differences in baseline hemodynamic function between hearts from ethanol (EtOH)-fed mice and controls. However, prior alcohol consumption doubled recovery of left ventricular developed pressure (68 8 vs. 33 8 mmHg for controls; n 10, P 0.05) and reduced creatine kinase release by half (0.26 0.04 vs. 0.51 0.08 U min 1 g wet wt 1 for controls; n 10, P 0.05). EtOH feeding doubled expression of activated protein kinase C epsilon (PKC) (n 6, P 0.05); whereas PKC inhibition blocked protection during ischemia-reperfusion. EtOH feeding also increased expression of Akt threeto fivefold (n 6, P 0.05), whereas PKC inhibition prevented increases in Akt kinase activity. We conclude that signaling pathways involving PKCare critical for sustained EtOH-mediated cardioprotection and that Akt may be a downstream effector of resistance to myocardial reperfusion injury.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ajpheart.physiology.org/content/ajpheart/283/1/H165.full.pdf
Language	English
Access Restriction	Open
Subject Keyword	Alcohol consumption Baseline (configuration management) Circa Circumference Creatine Kinase Downstream (software development) Ethanol Eucommia ulmoides Heart failure Hemodynamics Hypoxia-Ischemia, Brain Ischemia Maxima and minima Myocardial Reperfusion Injury PKC (conference) Protein Kinases Protein family Proto-Oncogene Proteins c-akt Reperfusion Therapy Scientific Publication Volume kinase activity torr
Content Type	Text
Resource Type	Article

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in