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Bicarbonate transport in cell physiology and disease.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Cordat, Emmanuelle Casey, Joseph R. |
| Copyright Year | 2009 |
| Abstract | The family of mammalian bicarbonate transport proteins are involved in a wide-range of physiological processes. The importance of bicarbonate transport follows from the biochemistry of HCO(3)(-) itself. Bicarbonate is the waste product of mitochondrial respiration. HCO(3)(-) undergoes pH-dependent conversion into CO(2) and in doing so converts from a membrane impermeant anion into a gas that can diffuse across membranes. The CO(2)-HCO(3)(-) equilibrium forms the most important pH buffering system of our bodies. Bicarbonate transport proteins facilitate the movement of membrane-impermeant HCO(3)(-) across membranes to accelerate disposal of waste CO(2), control cellular and whole-body pH, and to regulate fluid movement and acid/base secretion. Defects of bicarbonate transport proteins manifest in diseases of most organ systems. Fourteen gene products facilitate mammalian bicarbonate transport, whose physiology and pathophysiology is discussed in the present review. |
| Starting Page | 88 |
| Ending Page | 95 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.biochemj.org/content/ppbiochemj/417/2/423.full.pdf |
| PubMed reference number | 19099540v1 |
| Alternate Webpage(s) | https://doi.org/10.1042/BJ20081634 |
| DOI | 10.1042/bj20081634 |
| Journal | The Biochemical journal |
| Volume Number | 417 |
| Issue Number | 2 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anions Bicarbonates Biochemistry Carrier Proteins Cell physiology Human body Mammals Physiological Processes Sodium Bicarbonate Tissue membrane Waste Products bicarbonate ion bicarbonate transport body system physiological aspects |
| Content Type | Text |
| Resource Type | Article |
