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Effects of MK-801 and electroconvulsive shock on c-Fos expression in the rat hippocampus and frontal cortex
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ahn, Yong Min Kang, Ung Gu Park, Joo-Bae Kim, Yong Sik |
| Copyright Year | 2002 |
| Abstract | Both the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 and electroconvulsive shock (ECS) have been reported to induce c-Fos in rat brain. However, the former has anticonvulsant and psychotomimetic effects and the latter has proconvulsant and antipsychotic effects. To understand the mode of action of these treatments, the authors examined the effect of MK-801 and the interaction between MK-801 and ECS on the induction of c-Fos in the rat hippocampus and frontal cortex. MK-801 induced c-Fos in these brain regions in a nonlinear dose-response relationship. Maximum effect was achieved with 1-2 mg/kg of MK-801. The level of c-Fos paralleled animal hyperkinetic behavior, suggesting the role of c-Fos in the induced psychotomimetic behaviors. Pretreatment with MK-801 dose-dependently attenuated both the seizures and c-Fos expression by ECS. However, at an MK-801 pretreatment dose of 8 mg/kg, which completely blocked ECS-induced seizure, the induction of c-Fos was not completely blocked, suggesting non-NMDA mediated pathways of the induction of c-Fos by ECS. |
| Starting Page | 513 |
| Ending Page | 517 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0278-5846(01)00299-8 |
| PubMed reference number | 11999902 |
| Journal | Medline |
| Volume Number | 26 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0278584601002998 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0278584601002998?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0278-5846%2801%2900299-8 |
| Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
