NDLI: Cytosolic alcohol dehydrogenase (ADH) uses nicotinamide adenine dinucleotide (NAD) as an oxidizing agent. 1. The microsomal ethanol-oxidizing system (MEOS) uses nicotinamide adenine dinucleotide phosphate (NADPH) and molecular oxygen. The central enzyme of MEOS is cytochrome P-450 2E1 (CYP2E1). Etha

Content Provider	Semantic Scholar
Copyright Year	2012
Abstract	II.1. ETHANOL INDUCED HEPATIC TISSUE CHANGES II.1.1. Ethanol Ethanol is a commonly used substance among people all over the world with its intoxicating effects and potential for abuse. The main component of all alcoholic drinks is ethanol (ethyl alcohol). Ethanol is one of direct hepatotoxins agents, ethanol ingested in high doses impairs tissues by a variety of mechanisms, 17 oxidative stress plays surely a crucial role. Most ethanol is broken down (i.e., metabolized) in the liver through a series of chemical reactions, known as oxidation reactions, which involve hydrogen and oxygen atoms. In the predominant biological pathway for ethanol metabolism, called the alcohol dehydrogenase pathway (ADH), a second pathway of ethanol metabolism, the microsomal ethanol-oxidizing system (MEOS), is activated by long-term heavy ethanol consumption. 18
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Alternate Webpage(s)	http://eprints.undip.ac.id/35609/3/Chapter_2.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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