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Inflammatory bowel disease in children--clinical, endoscopic, radiologic and histopathologic investigation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Seo, Jeong Kee Yeon, Kyung Mo Chi, Je Geun |
| Copyright Year | 1992 |
| Abstract | This paper reviews our five years' clinical experience (1987 to 1991) of 22 patients with inflammatory bowel disease (IBD). There were 12 patients with Crohn's disease and 10 patients with ulcerative colitis. The mean age at diagnosis was 8.7 years (2 to 14 years). Clinical impressions before referral were chronic diarrhea in 11, irritable bowel syndrome in 5, colon polyp in 4, lymphoma in 3, intestinal tuberculosis in 2, amoebic colitis in 2, ulcerative colitis in 2 children and other diseases. The mean interval from the onset of symptoms to the diagnosis of IBD was 18 months. Diagnosis of Crohn's disease was delayed for more than 13 months in 8 (67%), whereas that of ulcerative colitis was delayed for more than 13 months in 4 (40%). Diarrhea (50%), abdominal pain (36%) and rectal bleeding (36%) were the three most frequent presenting complaints of IBD. Moderately severe abdominal pain was a more common chief complaint in Crohn's disease (58%) than in ulcerative colitis (10%). Hematochezia (90% vs 17%) and moderately severe diarrhea (90% vs 75%) were more common gastrointestinal manifestations in ulcerative colitis than in Crohn's disease. The associated extraintestinal manifestations were oral ulcer in 7, arthralgia in 11 and arthritis in 4, skin lesions in 2, eye lesions in 2 and growth failure in 9 patients. Of 12 children with Crohn's disease, granuloma was found in 5, aphthous ulcerations in 8, cobble stone appearance in 8, skip area or asymmetric lesions in 6, transmural involvement in 7, and perianal fistula in 3. Among 10 children with ulcerative Colitis, there were crypt abscess in 8, granularity or friability in 10 and rectosigmoid ulcerations with purulent exudate in 8 children. The main sites of involvement in children with Crohn's disease were both the small and large bowels in 7 (58%), small bowel only in 2 (16%), and colon only in 3 (25%). Terminal ileum involvement was seen in 75% of Crohn's disease cases. The main sites of involvement in children with ulcerative colitis were total colon in 4 (40%), up to the splenic flexure in 2 (20%), rectosigmoid in 3 (30%) and rectum only in one (10%). Medical treatment including sulfasalazine, and systemic or topical steroid was administered initially in most patients. Seven of 12 patients with Crohn's disease and 2 of 10 patients with ulcerative colitis were operated on.(ABSTRACT TRUNCATED AT 400 WORDS) |
| Starting Page | 221 |
| Ending Page | 235 |
| Page Count | 15 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://pdfs.semanticscholar.org/1a09/9354d12c8662dfbeac8db72b788fef4d1553.pdf |
| PubMed reference number | 1285921v1 |
| Volume Number | 7 |
| Journal | Journal of Korean medical science |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Abdominal Pain Amebic colitis Amoeba genus Aphthous Stomatitis Arthralgia Bacterial conjunctivitis Chronic diarrhea Colonic Polyps Crohn Disease Crypt abscesses Exudate Growth failure Histopathology Inflammatory Bowel Diseases Intestinal Diseases Intestines Intestines, Small Irritable Bowel Syndrome Large Intestinal Wall Tissue Left colic flexure Moderate Response Oral Ulcer Patient referral Patients Perianal Rectal hemorrhage Rectum and sigmoid colon Small Intestinal Wall Tissue Spleen Steroids Sulfasalazine TUBE,RECTAL,24FR,PLASTIC B#6510 Ulcerative Colitis eye lesion intestinal tuberculosis pathologic fistula procollagen Type I N-terminal peptide |
| Content Type | Text |
| Resource Type | Article |
