NDLI: Platelet and vascular function during coronary thrombolysis with tissue-type plasminogen activator.

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Platelet and vascular function during coronary thrombolysis with tissue-type plasminogen activator.

Content Provider	Semantic Scholar
Author	Roy, Louis
Copyright Year	1989
Abstract	Platelet activation may limit the response to tissue-type plasminogen activator (t-PA) during coronary thrombolysis in humans. As an index of platelet activation, we assessed thromboxane A2 biosynthesis during coronary thrombolysis with intravenous t-PA in patients with acute myocardial infarction. Urinary 2,3-dinor-thromboxane B2, a metabolite of thromboxane A2, was increased to a peak of 3,327 +/- 511 pg/mg creatinine (n = 12) following administration of intravenous t-PA and remained elevated for 48 hours. This increase was abolished by pretreatment with aspirin 325 mg orally (n = 6), indicating de novo biosynthesis of thromboxane A2 rather than washout of preformed metabolites during reperfusion. Prostacyclin (PGI2) biosynthesis, determined by excretion of 2,3-dinor-6-keto-PGF1 alpha, also increased after t-PA administration. However, this increase was less pronounced in patients who reperfused (28 +/- 3.3 ng.hr/mg creatinine) than in patients who failed to reperfuse (118 +/- 30 ng.hr/mg creatinine, p less than 0.05). These data provide evidence of platelet activation during coronary thrombolysis with t-PA. In patients who reperfuse, the reduction in PGI2 biosynthesis may be a marker of reperfusion injury to the vasculature and may further amplify platelet activation.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/80/6/1718.full.pdf
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/80/6/1718.full.pdf?download=true
PubMed reference number	2513144v1
Volume Number	80
Issue Number	6
Journal	Circulation
Language	English
Access Restriction	Open
Subject Keyword	Anabolism Aspirin Blood supply aspects Creatinine Epoprostenol Microgram per Kilogram Myocardial Infarction Oral cavity Patients Plasminogen Activator Platelet Activation Platelet Count measurement Reperfusion Injury Reperfusion Therapy Thrombolysis, function Thromboxane A2 Thromboxane B2 Thromboxanes alteplase
Content Type	Text
Resource Type	Article

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