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Protective cytotoxic T lymphocyte responses induced by DNA immunization against immunodominant and subdominant epitopes of Listeria monocytogenes are noncompetitive.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yamada, Tsutomu Uchiyama, Hiroshi Nagata, Toshi Uchijima, Masato Suda, Takafumi Chida, Kingo Nakamura, Hiroyuki Koide, Yukio |
| Copyright Year | 2001 |
| Abstract | Taking advantage of the fact that plasmid DNA encoding a single cytotoxic T lymphocyte (CTL) epitope can induce CTLs, we examined the influence of T-cell responses to dominant epitopes on those to a subdominant epitope derived from Listeria monocytogenes. Our data suggest that interaction between T cells against dominant and subdominant epitopes does not operate in the generation of the hierarchy. Furthermore, we found that a single dominant epitope is sufficient for the induction of protective immunity. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://iai.asm.org/content/69/5/3427.full.pdf |
| PubMed reference number | 11292768v1 |
| Volume Number | 69 |
| Issue Number | 5 |
| Journal | Infection and immunity |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cytotoxic T-Lymphocytes Epitopes Leukemia, B-Cell Listeria monocytogenes childhood lymphocyte depletion Hodgkin's lymphoma |
| Content Type | Text |
| Resource Type | Article |
