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Making matters worse for a broken heart.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Frey, Nick Olson, Eric N. |
| Copyright Year | 2000 |
| Abstract | Familial hypertrophic cardiomyopathy (FHC) is an autosomal-dominant inherited disease characterized by increased cardiac mass, arrhythmias, and sudden death. It has been estimated that as many as 1 in 500 people carry a mutation in a sarcomeric protein gene that can result in FHC (1). Myofilaments containing mutant sarcomeric proteins have been shown to exhibit alterations in calcium sensitivity, myofilament velocity, myosin ATPase activity, and maximum force development (reviewed in ref. 2). However, it remains unclear how these changes in the contractile apparatus transduce signals that result in hypertrophy and reprogramming of cardiac gene expression. |
| File Format | PDF HTM / HTML |
| DOI | 10.1172/JCI11733 |
| PubMed reference number | 11120749 |
| Journal | Medline |
| Volume Number | 106 |
| Issue Number | 12 |
| Alternate Webpage(s) | http://dm5migu4zj3pb.cloudfront.net/manuscripts/11000/11733/JCI0011733.pdf |
| Alternate Webpage(s) | https://doi.org/10.1172/JCI11733 |
| Journal | The Journal of clinical investigation |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
