NDLI: Preparation and therapeutic efficacy of polysorbate-80-coated amphotericin B/PLA-b-PEG nanoparticles.

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Preparation and therapeutic efficacy of polysorbate-80-coated amphotericin B/PLA-b-PEG nanoparticles.

Content Provider	Semantic Scholar
Author	Ren, Tianbin Xu, Ningwen Cao, Chunhong Yuan, Weizhong Yu, Xiao Qing Chen, Jianghan Ren, Jie
Copyright Year	2009
Abstract	Amphotericin B (AmB)/poly(lactic acid)-b-poly(ethylene glycol) (PLA-b-PEG) nanoparticles coated with polysorbate 80 (Tween-80) were prepared by nanoprecipitation for transport across the blood-brain barrier (BBB). The effects of Tween-80 on the size and distribution, entrapment efficiency and release behavior of AmB/PLA-b-PEG nanoparticles were investigated. Furthermore, the brain targeting and curative effect of coated nanoparticles were also investigated. The entrapment efficiency was significantly enhanced when nanoparticles were coated with Tween-80. The prepared nanoparticles were spherical with homogeneous distribution. Drug concentration in mice brain was greatly enhanced, which indicated that the coated nanoparticles could get across the BBB. Meanwhile, the AmB/PLA-b-PEG nanoparticles are able to reduce the toxicity of AmB to liver, kidney and blood system with improved therapeutic effect.
Starting Page	206
Ending Page	211
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://whale.to/vaccine/Tianbin+09+poly80+bbb%5B1%5D.pdf?origin=publication_detail
PubMed reference number	19622277v1
Alternate Webpage(s)	https://doi.org/10.1163/092050609X12457418779185
DOI	10.1163/092050609x12457418779185
Journal	Journal of biomaterials science. Polymer edition
Volume Number	20
Issue Number	10
Language	English
Access Restriction	Open
Subject Keyword	Adverse reaction to drug Amphotericin B Animal Testing Blood - brain barrier anatomy Eighty Entrapment of Medical Device or Device Component Polyethylene Glycols Polysorbates Renal Tissue cellular targeting peginterferon alfa-2b
Content Type	Text
Resource Type	Article

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