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Serum anti-Mullerian hormone throughout the human menstrual cycle.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Marca, Antonio La Stabile, Gaspare Artenisio, Alfredo Carducci Volpe, Annibale |
| Copyright Year | 2006 |
| Abstract | BACKGROUND The anti-Mullerian hormone (AMH) is a member of the transforming growth factor (TGF) superfamily. In women, AMH serum levels can be almost undetectable at birth, with a subtle increase noted after puberty. Data are lacking with regard to menstrual cycle day-to-day fluctuations. This longitudinal study was designed to investigate the pattern of secretion of AMH throughout the menstrual cycle in regularly cycling women. METHODS Twelve healthy female subjects aged 18-24 years participated in this study. Blood samples were taken every other day throughout one menstrual cycle. Serum FSH, LH, estradiol (E(2)), progesterone, inhibin B and AMH levels were assayed by double-antibody radioimmunoassay using commercial kits. RESULTS Serum AMH in the first days of the menstrual cycle (days -14 to -12) was 3.8 +/- 1.2 ng/ml (mean +/- SD). No significant changes were observed in serum AMH levels throughout the menstrual cycle. The highest value was 3.9 +/- 1.3 ng/ml at day -12 and the lowest value was 3.4 +/- 1.1 ng/ml at day 14, and the difference was not significant. CONCLUSION In this study, we demonstrated that serum AMH levels do not change significantly throughout the menstrual cycle. Hence, AMH exhibits a relatively stable expression during the menstrual cycle, making it an attractive determinant of ovarian activity. |
| Starting Page | 902 |
| Ending Page | 905 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/humrep/21/12/10.1093_humrep_del291/2/del291.pdf?Expires=1493728225&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=SOJbowgBNP8o25~eI3Kxx1lf4zfut0~PzzApgG2E~VKM83MJv5BN-02VOufokJM7jMVbflSwthB9i11JGoMuicLT30Jbbl5dhMWGHlExBifrSm0NNQ58Nx70IZebprOzQl2rzJGccrqafIZai0P3sJMlICejmp2r5x-8db6YIyyLdeffQCu6YVngQyZCgkby2R5aa~-F4YmV-6ROGZ9MXnnruBMz5JsgRsT1MywSoMI5~G40Ryr395vuofzF7GlO0BU4BE4XAuOG1CeOMJoAH8omUB7wgDvv2f1-UlS9BhrnTlMV-pcCwv7su~0gQWq-Tt55Clc4TiWggO1wrfOMww__ |
| PubMed reference number | 16923748v1 |
| Volume Number | 21 |
| Issue Number | 12 |
| Journal | Human reproduction |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Estradiol Exhibits as Topic Menstrual cycle Menstruation Microgram per Liter Physiological Sexual Disorders Progesterone Puberty Transforming Growth Factors inhibin B mullerian-inhibiting hormone |
| Content Type | Text |
| Resource Type | Article |
