NDLI: Tracheal suture in rats with hypothyroidism: wound healing study.

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Tracheal suture in rats with hypothyroidism: wound healing study.

Content Provider	Semantic Scholar
Author	Zimmermann, Elise Ribas-Filho, Jurandir Marcondes Malafaia, Osvaldo Ribas, Carmen Austrália Paredes Marcondes Nassif, Paulo Afonso Nunes Filho, Edmar Stieven Przysiezny, Paulo Eduardo
Copyright Year	2009
Abstract	PURPOSE To evaluate the influence of hypothyroidism in tracheal wound healing process. METHODS A controlled study was designed with 48 male Wistar rats, divided into two groups: study and control groups. In the first one hypothyroidism was surgically induced and 10 weeks after, a tracheal opening followed by suture was performed in both groups, subdivided into 7, 14, and 21 days in accordance with the date of animals death. A laboratorial evaluation was performed to prove the decreased in thyroid function in the study group. Also a macroscopic evaluation through a stablished protocol and a microscopic analysis with Hematoxylin-eosin and Sirius-Red staining methods were done. RESULTS The laboratorial evaluation certified suppressed thyroid function in the study group. The macroscopic evaluation showed the presence of suture blockade in the study group in all the evaluated days. Microscopic analysis showed a prolongated inflammatory process and less collagen with delay in organization in the study group comparing to control group. All these data were statistic significant. CONCLUSION Hypothyroidism had an influence in tracheal wound healing process, promoting delay in the inflammatory and organization processes and diminished tissue collagen quantity.
Starting Page	S709
Ending Page	S710
Page Count	2
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.scielo.br/pdf/acb/v24n4/07.pdf
PubMed reference number	19705026v1
Volume Number	24
Issue Number	4
Journal	Acta cirurgica brasileira
Language	English
Access Restriction	Open
Subject Keyword	Cessation of life Eosine Yellowish Hematoxylin and eosin stain method Hypothyroidism Operative Surgical Procedures Promotion (action) Pure Red-Cell Aplasia Staining method Thyroid Diseases Wound Healing
Content Type	Text
Resource Type	Article

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