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A quantum dot-based microRNA nanosensor for point mutation assays.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zeng, Ya-Ping Zhu, Guichi Yang, Xiaoyun Jing, Zhi-Liang Zhang, Chun-Yang |
| Copyright Year | 2014 |
| Abstract | We have developed a quantum dot-based microRNA nanosensor for point mutation assays using primer generation-mediated rolling circle amplification. The proposed method exhibits high sensitivity with a detection limit of as low as 50.9 aM and a large dynamic range of 7 orders of magnitude from 0.1 fM to 1 nM. Importantly, this method can be further applied to analyze the point mutation of mir-196a2 in the lung tissues of non small-cell lung cancer patients. |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c4cc02034k |
| PubMed reference number | 24853117 |
| Journal | Medline |
| Volume Number | 50 |
| Issue Number | 54 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/cc/c4/c4cc02034k/c4cc02034k1.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/c4cc02034k |
| Journal | Chemical communications |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |