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Production and Roles of Glial Tissue Inhibitor of Metalloproteinases-1 in Human Immunodeficiency Virus-1-Associated Dementia Neuroinflammation: A Review.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chao, C. Ghorpade, Anuja |
| Copyright Year | 2009 |
| Abstract | PROBLEM STATEMENT: Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and its cognate targets, the Matrix Metalloproteinases (MMPs), were differentially expressed in human brain samples with or without HIV-1 infection or HIV-1 Encephalitis (HIVE). APPROACH: A through literature review demonstrated that cell culture models of Central Nervous System (CNS) cell types had been used to illustrate the intricate temporal patterns of TIMP-1/MMP expression, regulated by a variety of inflammatory cytokines. RESULTS: As MMPs and TIMP-1 can significantly altered the extracellular environment and cell signaling, the differential regulation of TIMP-1/MMP expression in neuroinflammation can impact neuronal function and survival in disease conditions. TIMP-1 pro-survival effects had been demonstrated in a variety of cell types including CNS neurons, protecting cells from a wide range of stress and insults. TIMP-1, also known to interact with non-MMP targets, altered cell behavior. In this review, we discussed the possibility that the upregulation of TIMP-1 by glia in acute neuroinflammation may be a neuroprotective response. CONCLUSION: It will be important to delineate the effects of TIMP-1 on neurons and identify receptors and downstream signaling pathways, in order to evaluate TIMP-1 as a therapeutic strategy for neuroinflammatory and neurodegenerative diseases. |
| Starting Page | 314 |
| Ending Page | 320 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://thescipub.com/PDF/ajidsp.2009.307.313.pdf |
| PubMed reference number | 20585405v1 |
| Volume Number | 5 |
| Issue Number | 4 |
| Journal | American journal of infectious diseases |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alzheimer's Disease CNS disorder Cell Culture Techniques HIV Immunologic Deficiency Syndromes Matrix Metalloproteinases Metalloproteases Neurodegenerative Disorders Neurogenic Inflammation Neuroglia Presenile dementia TIMP1 protein, human Tissue-Inhibitor of Metalloproteinase-1 Varicella Zoster Encephalitis cell type |
| Content Type | Text |
| Resource Type | Article |
