NDLI: 3 4 Title : 5 Assessment of the physical properties and stability of mixtures of tetracycline 6 hydrochloride ointment and acyclovir cream 7 8 9

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3 4 Title : 5 Assessment of the physical properties and stability of mixtures of tetracycline 6 hydrochloride ointment and acyclovir cream 7 8 9

Content Provider	Semantic Scholar
Author	Inoue, Yutaka Furuya, Kayoko Rikimaru Murata, Isamu Kanamoto, Ikuo
Copyright Year	2013
Abstract	18 In dermatology, ointments are often mixed as part of drug therapy, but mixing 19 often leads to incompatibility. Three combinations of tetracycline ointment (TC-o) and 20 acyclovir cream (ACV-cr) were prepared at a TC-o:ACV-cr ratio of 1:1 using a 21 brand-name ACV-cr and two generic ACV-cr (samples TC-o+ACV-A, TC-o+ACV-B, 22 and TC-o+ACV-C). Microscopic examination revealed separation in TC-o+ACV-C. 23 Viscosity and elasticity measurement indicated that the storage modulus (G’) and loss 24 modulus (G”) of each of the TC-o+ACV-cr mixtures behaved similarly to those of an 25 ACV-cr and the loss tangent (tanδ) behaved similarly to that of a TC ointment. In 26 addition, differences in the storage modulus (G’) and loss modulus (G”) of the 27 TC-o+ACV-cr mixtures were noted. To assess stability, each TC-o+ACV-cr mixture 28 was stored away from direct sunlight at 25oC and an RH of 84% and at 4oC (in a 29 refrigerator). HPLC revealed that the ACV content in each TC-o+ACV-cr mixture 30 remained at 95–105% for up to 14 days under both sets of storage conditions. A 31 decline in TC content in each TC-o+ACV-cr mixture was not noted with storage at 4oC 32 but was noted over time with storage at 25oC and an RH of 84%. In addition, 33 significant differences in the percent decline in TC content in each TC-o+ACV-cr 34 mixture occurred with storage at 25oC and an RH of 84%. Thus, differences in 35 physical properties and stability may occur when combining brand-name and generic 36 drugs, and temperature and humidity may be the cause of the TC-o’s incompatibility. 37 38
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://libir.josai.ac.jp/il/user_contents/02/G0000284repository/pdf/JOS-j.ijpharm.2013.02.047.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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