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Monitoramento da degradação eletroquímica de fármacos em água usando anodos de diamante dopado com boro empregando espectroscopia UV/Vis e resolução de curva multivariada
| Content Provider | Semantic Scholar |
|---|---|
| Author | Paiva, Juliana Cerqueira De |
| Copyright Year | 2012 |
| Abstract | Electrochemical degradation of the pharmaceuticals diclofenac sodium, oxytetracycline hydrochloride and chlortetracycline hydrochloride using boron-doped diamond (BDD) anodes were performed in this work. The diamond films were deposited on silicon and niobium cylinders and niobium plates using the chemical vapor deposition (CVD). Characterizations were carried out using scanning electron microscopy (SEM) and Raman spectroscopy. For both substrates, the results indicated polycrystalline diamond and adherent films, without cracks or delamination. Pharmaceuticals were monitored during electrolysis by discrete sampling by analysis of total organic carbon (TOC) and chemical oxygen demand (COD) and continuously by ultraviolet-visible (UV/Vis) spectroscopy. Chemometric methods such as evolving factor analysis (EFA), SIMPLISMA (simple-to-use interactive self-modeling mixture analysis) and multivariate curve resolution-alternating least squares (MCR-ALS) were applied to spectroscopic data to monitoring the degradation kinetics of the original components and their byproducts. Pharmaceuticals were degraded individually and in ternary mixtures. All experiments performed had satisfactory removal of COD, TOC and decrease in absorbance. Significant differences were not observed in respect to substrate shapes on electrodegradation efficiency. The spectra UV/Vis analytical methodology coupled with MCR-ALS method presented to be very promising since it is possible to solve the pure spectra profiles of all the original components in addition to the concentration profiles. Although the resolution obtained, the study was inconclusive in respect to byproducts generated, since a rank deficiency was observed. However, the methodology used for continuous monitoring of the degradation of chemical species that absorb in the UV/Vis range proved to be simple, efficient and reasonably selective for this purpose.%%%%Degradacoes eletroquimicas dos farmacos diclofenaco de sodio, hidrocloreto de oxitetraciclina e hidrocloreto de clorotetraciclina empregando anodos de diamante dopado com boro (BDD) foram realizadas neste trabalho. Os filmes de diamante foram depositados sobre cilindros de niobio e silicio e placas de niobio usando a deposicao por vapor quimico (CVD). As caracterizacoes foram realizadas usando microscopia eletronica de varredura (SEM) e espectroscopia Raman. Para ambos os substratos, os resultados indicaram filmes de diamante policristalinos aderentes, sem rachaduras ou delaminacoes. As eletrolises dos farmacos foram monitoradas por amostragem discreta atraves das analises de carbono orgânico total (TOC) e demanda quimica de oxigenio (COD) e continuamente atraves de espectroscopia na regiao ultravioleta-visivel (UV/Vis). Metodologias quimiometricas, tais como a analise dos fatores evoluintes (EFA), SIMPLISMA (simple-to-use interactive self-modeling mixture analysis) e resolucao de curva multivariada com quadrados minimos alternados (MCR-ALS), foram aplicadas aos dados espectroscopicos para acompanhar a cinetica de degradacao dos… |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.locus.ufv.br/bitstream/handle/123456789/2137/texto%20completo.pdf?isAllowed=y&sequence=1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
