Selective vancomycin detection using optical fibre long period gratings functionalised with molecularly imprinted polymer nanoparticles.

Content Provider	Semantic Scholar
Author	Korposh, Sergiy Chianella, Iva Guerreiro, Antonio Caygill, Sarah Piletsky, Sergey A. James, Stephen Tatam, Ralph P.
Copyright Year	2014
Abstract	An optical fibre long period grating (LPG) sensor modified with molecularly imprinted polymer nanoparticles (nanoMIPs) for the specific detection of antibiotics is presented. The operation of the sensor is based on the measurement of changes in refractive index induced by the interaction of nanoMIPs deposited onto the cladding of the LPG with free vancomycin (VA). The binding of nanoMIPs to vancomycin was characterised by a binding constant of 4.3 ± 0.1 × 10(-8) M. The lowest concentration of analyte measured by the fibre sensor was 10 nM. In addition, the sensor exhibited selectivity, as much smaller responses were obtained for high concentrations (∼700 μM) of other commonly prescribed antibiotics such as amoxicillin, bleomycin and gentamicin. In addition, the response of the sensor was characterised in a complex matrix, porcine plasma, spiked with 10 μM of VA.
File Format	PDF HTM / HTML
DOI	10.1039/c3an02126b
PubMed reference number	24634909
Journal	Medline
Volume Number	139
Issue Number	9
Alternate Webpage(s)	https://lra.le.ac.uk/bitstream/2381/33374/2/LPG-Vancom-r2_final.pdf
Alternate Webpage(s)	http://pubs.rsc.org/en/content/articlepdf/2014/AN/C3AN02126B
Alternate Webpage(s)	https://lra.le.ac.uk/bitstream/2381/33374/3/c3an02126b.pdf
Alternate Webpage(s)	https://pubs.rsc.org/en/content/getauthorversionpdf/C3AN02126B
Alternate Webpage(s)	https://pubs.rsc.org/en/content/articlepdf/2014/an/c3an02126b
Alternate Webpage(s)	https://doi.org/10.1039/c3an02126b
Journal	The Analyst
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article