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Serum levels of 5-androstene-3β, 7β-DIOL sulphate, 5α-androstane-3α,17β-DIOL sulphate and glucuronide, in late onset 21-hydroxylase deficiency
| Content Provider | Semantic Scholar |
|---|---|
| Author | Montalto, Joseph G. Funder, John W. Yong, Arthur B. W. Whorwood, Christopher B. Connelly, John F. |
| Copyright Year | 1990 |
| Abstract | Abstract Serum sulphates of 5-androstene-3β,17β-diol (5-ADIOL-S), 5α-androstane-3α,17β-diol (3α-DIOL-S) and dehydroepiandrosterone (DHEA-S), as well as 5α-androstane-3α,17β-diol glucuronide (3α-DIOL-G) and unconjugated androstenedione (AD) and testosterone (T), sex hormone binding globulin (SHBG), free androgen index (FAI) and 17α-hydroxyprogester-ne (17OHP) were measured by specific radioimmunoassays (RIA) in 14 women with late-onset 21-hydroxylase deficiency (LOCAH), and in normal women ( n = 73). The diagnosis of LOCAH was made on the finding of a (17OHP) response level greater than 30 nmol/1 following ACTH stimulation, and/or an elevation of urinary metabolites of 17OHP. Mean values for serum concentrations of all steroids measured and the free androgen index (100 × T nmol/1 ÷ SHBG nmol/1) were significantly elevated, and SHBG levels depressed in patients with LOCAH. These studies show that in LOCAH, in addition to the unconjugated steroids AD and T, the sulphoconjugated steroids DHEA-S, 5-ADIOL-S and 3α-DIOL-S are increased, as is the glucuronide conjugate 3α-DIOL-G and the index of bioavailable testosterone (FAI), and that mean SHBG levels are depressed. These data suggest that as well as AD, 5-ADIOL-S and DHEA-S may act as pro-hormones for more potent steroids (T and 5α-dihydrotestosterone) in peripheral tissues, while 3α-DIOL-S and 3α-DIOL-G may both reflect peripheral androgen metabolism in patients with LOCAH. |
| Starting Page | 593 |
| Ending Page | 598 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0960-0760(90)90406-B |
| Volume Number | 37 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/096007609090406B |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/096007609090406B?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0960-0760%2890%2990406-B |
| Journal | The Journal of Steroid Biochemistry and Molecular Biology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
