NDLI: Neoplastic-like transformation effect of single-walled and multi-walled carbon nanotubes compared to asbestos on human lung small airway epithelial cells.

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Neoplastic-like transformation effect of single-walled and multi-walled carbon nanotubes compared to asbestos on human lung small airway epithelial cells.

Content Provider	Semantic Scholar
Author	Wang, Liying Stueckle, Todd A. Mishra, Anurag Derk, Raymond Meighan, Terence G. Castranova, Vincent Rojanasakul, Yon
Copyright Year	2014
Abstract	Accumulating evidence indicates that carbon nanotubes (CNTs) are biopersistent and can cause lung damage. With similar fibrous morphology and mode of exposure to asbestos, a known human carcinogen, growing concern has arisen for elevated risk of CNT-induced lung carcinogenesis; however, relatively little is known about the long-term carcinogenic effect of CNT. Neoplastic transformation is a key early event leading to carcinogenesis. We studied the ability of single- and multi-walled CNTs to induce neoplastic transformation of human lung epithelial cells compared to asbestos. Long-term (6-month) exposure of the cells to occupationally relevant concentrations of CNT in culture caused a neoplastic-like transformation phenotype as demonstrated by increased cell proliferation, anchorage-independent growth, invasion and angiogenesis. Whole-genome expression signature and protein expression analyses showed that single- and multi-walled CNTs shared similar signaling signatures which were distinct from asbestos. These results provide novel toxicogenomic information and suggest distinct particle-associated mechanisms of neoplasia promotion induced by CNTs and asbestos.
Starting Page	485
Ending Page	507
Page Count	23
File Format	PDF HTM / HTML
DOI	10.3109/17435390.2013.801089
PubMed reference number	23634900
Journal	Medline
Volume Number	8
Issue Number	5
Alternate Webpage(s)	https://stacks.cdc.gov/view/cdc/34868/cdc_34868_DS1.pdf
Alternate Webpage(s)	https://doi.org/10.3109/17435390.2013.801089
Journal	Nanotoxicology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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