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Diaphragm pacing and noninvasive respiratory management of amyotrophic lateral sclerosis/motor neuron disease.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mahajan, Kedar R. Bach, John R. Saporito, Lou R. Perez, Nick |
| Copyright Year | 2012 |
| Abstract | INTRODUCTION Although it is known that continuous noninvasive ventilation (CNIV) can prolong life in amyotrophic lateral sclerosis/motor neuron disease (ALS/MND), in this study we explore similar claims for diaphragm pacing (DP). METHODS NIV and DP users' vital capacities (VCs) over time and duration of NIV and CNIV dependence were analyzed for 354 non-DP and 8 DP ALS/MND patients. RESULTS Patients had a higher rate of monthly VC decline before NIV use (5.1 ± 7.6%) than during NIV use (2.5 ± 3.6%) (P < 0.01, 95% CI 0.84-4.5); the decline for 4 DP users was 3.7-20%. Fifty-five ALS/MND patients used part-time NIV for 19.9 ± 27.6 months until tracheostomy/death, whereas 113 others used it for 10.9 ± 10.5 months until CNIV dependence for another 12.8 ± 16.2 months. After placement, 7 DP users were CNIV dependent in 8.0 ± 7.0 months, whereas 6 underwent tracheostomy/died in 18.2 ± 13.7 months. CONCLUSIONS CNIV prolonged the survival of 113 of the 354 non-DP and 6 DP ALS/MND patients by 12.8 and 10.2 months, respectively. DP provided no benefit on VC or mechanical ventilation-free survival. |
| Starting Page | 578 |
| Ending Page | 590 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.alscareproject.org/respresearch/DP-Vs-NIV-in-ALS.pdf |
| PubMed reference number | 23042087v1 |
| Alternate Webpage(s) | https://doi.org/10.1002/mus.23663 |
| DOI | 10.1002/mus.23663 |
| Journal | Muscle & nerve |
| Volume Number | 46 |
| Issue Number | 6 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Amyotrophic Lateral Sclerosis Antilymphocyte Serum Cessation of life Diaphragmatic Eventration Mechanical ventilation Motor Neuron Disease Motor Neurons Nipah Virus Noninvasive Ventilation Patients Respiration Tracheostomy procedure Vital capacity murine nodule inducing virus |
| Content Type | Text |
| Resource Type | Article |
