NDLI: Early pathogenic event of Alzheimer’s disease documented in iPSCs from patients with PSEN1 mutations

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Early pathogenic event of Alzheimer’s disease documented in iPSCs from patients with PSEN1 mutations

Content Provider	Semantic Scholar
Author	Yang, Juan Zhao, Hanzhi Shi, Guilai Song, Jian Tang, Yu Li, Song Li, Ting Tang, Fan Gu, Junjie Zhang, Lingling Zhang, Zhuohua Zhang, Xiaohui Jin, Ying Le, Weidong
Copyright Year	2017
Abstract	Alzheimer's disease (AD) is the most common age-related dementia characterized by progressive neuronal loss. However, the molecular mechanisms for the neuronal loss is still debated. Here, we used induced pluripotent stem cells (iPSCs) derived from somatic cells of familial AD patients carrying PSEN1 mutations to study the early pathogenic event of AD. We found that premature neuronal differentiation with decreased proliferation and increased apoptosis occured in AD-iPSC-derived neural progenitor cells (AD-NPCs) once neuronal differentiation was initiated, together with higher levels of Aβ42 and phosphorylated tau. Premature neuronal differentiation in AD-NPCs was caused by PSEN1 mutations and might be correlated to multiple dysregulated processes including but not limited to Wnt-Notch pathway. Our study documented previously unappreciated early NPC dysfunction in AD-NPCs, providing valuable new insights into the early mechanisms underlying AD pathogenesis.
Starting Page	7900
Ending Page	7913
Page Count	14
File Format	PDF HTM / HTML
DOI	10.18632/oncotarget.13776
Alternate Webpage(s)	http://brain.bnu.edu.cn/home/xhzhang/pdf/AD-iPS-pathologies-Oncotarget2016.pdf
Alternate Webpage(s)	http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=13776&path%5B%5D=44812
PubMed reference number	27926491
Alternate Webpage(s)	https://doi.org/10.18632/oncotarget.13776
Journal	Medline
Volume Number	8
Journal	Oncotarget
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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