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TERT rs2736098 (Ex2-659G>A) polymorphism and cancer susceptibility: evidence from a comprehensive meta-analysis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Pang, Tingyuan Zhou, Minjie Liu, Rumin Luo, Jia Xia, Renfei |
| Copyright Year | 2017 |
| Abstract | Increasing researches have been performed regarding the relationship between TERT rs2736098 and cancer risk, but no consensus has been reached about the relationship. Here, we conducted this updated meta-analysis, aiming to comprehensively evaluate the role of TERT rs2736098 in cancer risk. We systematically searched potential relevant articles through PubMed, EMBASE, CNKI, and WanFang database before August 2017. A total of 33 studies with 18685 cases and 23820 controls were finally included in the current meta-analysis. We then adopted odds ratios (ORs) and 95% confidence intervals (CIs) to analyze the contributions of TERT rs2736098 to cancer risk. We found that the TERT rs2736098 polymorphism was associated with risk of cancer in overall analysis (AA vs. GG: OR = 1.26, 95% CI = 1.09-1.47; AA vs. AG/GG OR = 1.22, 95% CI = 1.09-1.36; AA/AG vs. GG: OR = 1.13, 95% CI = 1.02-1.24; A vs. G: OR = 1.11, 95% CI = 1.04-1.20). Furthermore, in analysis stratified by cancer type, ethnicity, control source, quality score, and Hardy-Weinberg equilibrium (HWE) in controls, we found increased risk of cancer among lung cancer, bladder cancer, breast cancer, colorectal cancer, other cancers, Asians, hospital-based subgroup, score > 9 group, as well as controls agreement with HWE group. Despite some limitations, the current meta-analysis represented the largest and the most comprehensive investigations, with the strongest conclusion than ever before. To further explicit the association between TERT rs2736098 and cancer risk, more well-design case-control studies with larger sample size are warranted in the future. |
| Starting Page | 96433 |
| Ending Page | 96441 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=21703&path%5B%5D=68885 |
| PubMed reference number | 5707112 |
| Alternate Webpage(s) | https://doi.org/10.18632/oncotarget.21703 |
| DOI | 10.18632/oncotarget.21703 |
| Journal | Oncotarget |
| Volume Number | 8 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Amino Acids Bladder Neoplasm Breast Carcinoma CYP17A1, 7-BP DUP, EX2 Carcinoma of lung Colorectal Cancer Colorectal Carcinoma Confidence Intervals Entity Name Part Qualifier - adopted Gated Blood-Pool Imaging Large Malignant neoplasm of urinary bladder Mammary Neoplasms Odds Ratio Silver tert-Butyl Alcohol |
| Content Type | Text |
| Resource Type | Article |
