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Formulation and evaluation of self emulsifying drug delivery system (SEDDS) of Indomethacin
| Content Provider | Semantic Scholar |
|---|---|
| Author | Saritha, Duddukuru Nagaraju, Rapuri |
| Copyright Year | 2014 |
| Abstract | 3 ABSTRACTof present study was to develop a stable formulation for self emulsifying drug delivery systems (SEDDS) in order to enhance the solubility, release rate, and oral absorption of the poorly soluble drug, indomethacin. Based on the solubility of indomethacin in oil, surfactant and cosurfactant, pseudo-ternary phase diagrams were developed for SEDDS composed of labrafil, cremophor EL and transcutol P. Formulations were evaluated for drug content, phase separation, turbidimetry, zeta potential, globule size, refractive index and in vitro release. All formulations showed globule size in nanometric range, good stability with no phase separation, and rapidly formed emulsion which was clear. All formulations showed more than 90% of drug release at the end of 60 min. The SEDDS showed improved dissolution rate compared to Indocin (marketed product). Anti-inflammatory studies were conducted in Wistar strain male albino rats and indomethacin SEDDS showed more significant activity than the marketed product. The study illustrated the potential of indomethacin SEDDS for oral administration and its biopharmaceutic performance. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.ijrpsonline.com/pdf/2023.pdf |
| Alternate Webpage(s) | http://ijrpsonline.com/down_2023.php |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
