NDLI: Benzalkonium Chloride Induced Bronchoconstriction in Patients with Stable Bronchial Asthma

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Benzalkonium Chloride Induced Bronchoconstriction in Patients with Stable Bronchial Asthma

Content Provider	Semantic Scholar
Author	Lee, Byoung Hoon Kim, Sang-Hoon
Copyright Year	2007
Abstract	BACKGROUND Although benzalkonium chloride (BAC)-induced bronchoconstriction occurs in patients with bronchial asthma, BAC-containing nebulizer solutions are still being used in daily practice in Korea. The aim of this study was to evaluate the effects of inhaled aqueous solutions containing BAC. METHODS Thirty subjects with bronchial asthma and 10 normal controls inhaled up to three 600 microg nebulized doses of BAC using a jet nebulizer. FEV1 (forced expiratory volume at one second) was measured 15 minutes after each dose. Inhalations were repeated every 20 minutes until FEV1 decreased by 15% or more (defined as BAC-induced bronchoconstriction) or the 3 doses were administered. RESULTS The percent fall in FEV1 in response to BAC inhalation was significantly higher in asthmatics than in normal subjects (p < 0.05). BAC administration in subjects with asthma reached a plateau (maximal effect). BAC-induced bronchoconstriction was found in 6 asthmatics (20%), with two responders after the 2nd inhalation and 4 after the 3rd inhalation. The percent fall in FEV1 in response to the 1st inhalation of BAC was significantly higher in asthmatics with higher bronchial hyperresponsiveness (BHR) than in those with lower BHR. CONCLUSIONS This study suggests that the available multi-dose nebulized solution is generally safe. However, significant bronchoconstriction can occur at a relatively low BAC dose in asthmatics with severe airway responsiveness.
Starting Page	244
Ending Page	248
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.kjim.org/upload/2204244.pdf
PubMed reference number	18309682v1
Volume Number	22
Journal	The Korean journal of internal medicine
Language	English
Access Restriction	Open
Subject Keyword	Airway Obstruction Asthma Benzalkonium Chloride Bronchial Hyperreactivity Bronchoconstriction [PE] Expiration, function Forced expiratory volume procedure Inhalation Dosing Unit Inspiration function Nebulizers Numerous Patients Pulmonary Function Test/Forced Expiratory Volume 1 Solutions nebulized body site
Content Type	Text
Resource Type	Article

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