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Author's response to reviews Title: Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: effect of gender and age. EPIRCE cross-sectional study. Authors:
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gayoso-Diz, Pilar Rodríguez-Álvarez, María Xosé Gude, Francisco Garcia, Fernando Gayoso, Pilar Kamezaki, Fumihiko |
| Copyright Year | 2013 |
| Abstract | 1.Background: Ln2, add a period after “metabolic risk”; Response: This change has been made. Ln 4, change “describes” to “describe”. Response: This change has been made. The third sentence “To describe the influence of...” is incomplete. Please change it to “The purpose of this study was to describe ...”. Response: The text: “To describe the influence of age and gender in the estimation of HOMA-IR optimal cut-off values ...” has been replaced by “The purpose of this study was to describe the influence of age and gender in the estimation of HOMA-IR optimal cut-off values ...” 2.Methods: Ln 6, change “classified” to “classifying”. Response: This change has been made. 3.Results: Ln2, please change “...to 2.05 take into account MetS components.” to “...to 2.05 taking into account of MetS components”. Response: The text: “..to 2.05 take into account MetS components.” has been replaced by ““...to 2.05 taking into account of MetS components”. BACKGROUND 4.P3, Ln7-8, the sentence of “However, no take into account the ability of proposed cutoff points to identify risk of clinically relevant outcomes.” is still somewhat confusing. Did the authors intend to mean that “However, no studies have examined the ability of proposed cutoff points to ....”? Response: The text: “However, no take into account the ability of proposed cutoff points to identify ...” has been replaced by “However, no studies have examined the ability of proposed cutoff points to identify....” 5.P3, Ln9, change “being” to “been”. Response: This change has been made. METHODS Specific laboratory determinations 6.P1, Ln, 3, the kit used to measure fasting insulin level was not added. Response: We agree with referee, in previous review document there was a mistake and the kit udes to measure fasting insulin levels was not added. The text: “Fasting insulin levels were measured using a radioimmunoassay (RIA) method” has been replaced with “Fasting insulin levels were measured using a radioimmunoassay (RIA) method (Coat A Count Insulin, Los Angeles, USA)” RESULTS AUC values of HOMA-IR by gender and diabetes status 7.P1, Ln6, the referenced table should be “Table 3”, instead of “Table 2”, after re-numbering the tables. Response: This change has been made. DISCUSSION 8.P5, Ln7-10, the same statement of “The consideration of the attendant risk of cardiovascular and metabolic diseases to establish this cut-off point would increase its clinical utility in identifying those patients in whom the presence of multiple metabolic risk factors imparts an increased metabolic and cardiovascular risk.” appeared three times in the manuscript, including the Abstract, Discussion, and Conclusions. Please re-write/paraphrase to avoid repeating the exact statements three times. Response: The text: “The consideration of the attendant risk of cardiovascular and metabolic diseases to establish this cut-off point would increase its clinical utility in identifying those patients in whom the presence of multiple metabolic risk factors imparts an increased metabolic and cardiovascular risk.” has been replaced by “To increase the clinical utility of HOMA-IR values, we study its ability to classify those individuals with multiple metabolic risk factors. ” Table 1 9.Please add the actual numbers of subjects who had metabolic síndrome among women and men with or without diabetes, using ATP III and IDF criteria. For example, 11.1% (159), 14.9% (152). Response: We have added the numbers of subjects who had MetS among men and women, with and without diabetes, using ATPIII and IDF criteria. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://static-content.springer.com/openpeerreview/art:10.1186%2F1472-6823-13-47/12902_2013_201_AuthorComment_V3.pdf |
| Alternate Webpage(s) | https://static-content.springer.com/openpeerreview/art:10.1186%2F1472-6823-13-47/12902_2013_201_AuthorComment_V2.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
