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Evaluation of Anti-Hyperlipidemic Activity of Extracted Alpha- Linolenic Acid from Natural Linum usitatissimum Compared with Atorvastatin in High Fat Diet Induced Rats
| Content Provider | Semantic Scholar |
|---|---|
| Copyright Year | 2020 |
| Abstract | Linum usitatissimum (LU) has a lipid-lowering action in both normal and diabetic animals. Because OS leaves are rich in oil, the present study was conducted to explain the antihyperlipidemic and organ-protective effect of LU fixed oil in rats fed with a high fat (HF) diet. LU fixed oil was extracted by hexane and the fatty acids composition identified by GC-MS. Four groups of male Wistar rats included a normal control group, a high fat fed-diet (HF) group, a HF group treated with LU fixed oil, and a HF group treated with a reference drug Atorvastatin. The results show that LU fixed oil contains five kinds of fatty acids, of which alpha-linolenic acid was the major fatty acid. LU fixed oil depressed high serum levels of total cholesterol, triglyceride, LDL-C, and AI, whereas no significant effect on HDL-C was observed. LU fixed oil also suppressed high levels of liver cholesterol and triglyceride with no significant effect on both lipids in feces. In addition, LU fixed oil normalized the high serum levels of LDH and CK-MB but no significant effect on high serum levels of ALT, AST, and ALP was obtained. We conclude that treatment with LU fixed oil during the last three weeks of HF diet feeding decreased the high serum lipid profile and expressed antiartherogenic and cardioprotective actions against hyperlipidemia. The antihyperlipidemic action of OS fixed oil was mainly resulted from the suppression of liver lipid synthesis. Linolenic acid and linoleic acid contained in LU fixed oil were possibly responsible for both lipid-lowering and cardiac protective action against hyperlipidemia. Yerram Mounika, Ramavath Mohanbabu naik 1. Department of Pharmacology, Surabhi Dayakar rao college of Pharmacy, Gajwel (mandal), Siddipet(district), Telangana-502312. 2. Asst Professor, Department of Pharmaceutical Analysis and Quality Assurance, Gland institute of pharmaceutical science, Kothapet (v), Near Narsapur, Medak (district), Telangana-502334. Submission: 27 November 2019 Accepted: 2 December 2019 Published: 30 December 2019 www.ijppr.humanjournals.com Citation: Yerram Mounika et al. Ijppr.Human, 2019; Vol. 17 (1): 306-328. 307 INTRODUCTION Hyperlipidemia is an excess of fatty substances called lipids, largely cholesterol and triglycerides, in the blood. It is also called hyperlipoproteinemia because these fatty substances travel in the blood attached to proteins. This is the only way that these fatty substances can remain dissolved while in circulation. Hyperlipidemia disease has afflicted humankind since antiquity. The treasure house of plant kingdom has a number of plants to treat this ailment. The indigenous system of medicine provides an abundant data about plants available for treatment of hyperlipidemia. A lot of work has been carried out by researches on various plants to evident their effectiveness in hyperlipidemia. But still lots many are left which are used in the indigenous system but no systematic studies regarding their pharmacology have been carried out. One such natural medicine in indigenous system of medicine claimed to be useful in treatment of high fat deposition in various organs. Alpha-linolenic acid is natural medicine extracts from capsicum and other pepper plants the systematic pharmacological study is carried out to support its hyperlipidemic activity. Current study is undertaken to evaluate whether the Alpha-linolenic acid possesses antioxidant and antihyperlipidemic activity and able to increase liver protection. So the purpose of present study is to evaluate effect of Alpha-linolenic acid on hyperlipidemia. Here the parameters included are: ▪ Oxidative stress in liver ▪ Serum cholesterol and HDL cholesterol and Total protein levels ▪ Histopathology of liver and carotid artery in rats |
| File Format | PDF HTM / HTML |
| DOI | 10.33140/jpr.05.01.03 |
| Alternate Webpage(s) | http://ijppr.humanjournals.com/wp-content/uploads/2020/01/25.Yerram-Mounika-Ramavath-Mohanbabu-naik.pdf |
| Alternate Webpage(s) | https://doi.org/10.33140/jpr.05.01.03 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
