NDLI: NADPH oxidase deficiency in X-linked chronic granulomatous disease.

Content Provider	Semantic Scholar
Author	Hohn, David C. Lehrer, Robert I.
Copyright Year	1975
Abstract	We measured the cyanide-insensitive pyridine nucleotide oxidase activity of fractionated resting and phagocytic neutrophils from 11 normal donors, 1 patient with hereditary deficiency of myeloperoxidase, and 7 patients with X-linked chronic granulomatous disease (CGD). When measured under optimal conditions (at pH 5.5 and in the presence of 0.5 mM Mn++), NADPH oxidase activity increased fourfold with phagocytosis and was six-fold higher than with NADH. Phagocytic neutrophils from patients with CGD were markedly deficient in NADPH oxidase activity.
Starting Page	1033
Ending Page	1036
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://dm5migu4zj3pb.cloudfront.net/manuscripts/107000/107980/JCI75107980.pdf
PubMed reference number	235560v1
Volume Number	55
Issue Number	4
Journal	The Journal of clinical investigation
Language	English
Access Restriction	Open
Subject Keyword	Chronic granulomatous disease Cyanides NADH NADP NADPH Oxidase Nucleotides Patients Peroxidase Phagocytosis Pyridines Rest X-Linked Combined Immunodeficiency Diseases pyridine nucleotide
Content Type	Text
Resource Type	Article

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