NDLI: High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas.

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High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas.

Content Provider	Semantic Scholar
Author	Liu, Vincent Wing Sun Shi, Honghui Cheung, Annie N. Y. Leung, T. W. Nagley, Phillip Wong, L.-J. Ngan, Hextan Yuen-Sheung
Copyright Year	2001
Abstract	To investigate the potential role of somatic mitochondrial DNA (mtDNA) mutations in tumorigenesis, the occurrence of mutations in mtDNA of ovarian carcinomas was studied. We sequenced the D-loop region of mtDNA of 15 primary ovarian carcinomas and their matched normal controls. Somatic mtDNA mutations were detected in 20% (3 of 15) tumor samples carrying single or multiple changes. Complete sequence analysis of the mtDNA genomes of another 10 pairs of primary ovarian carcinomas and control tissues revealed somatic mtDNA mutations in 60% (6 of 10) of tumor samples. Most of these mutations were homoplasmic, and most were T-->C or G-->A transitions, but one represented a differential length within a run of identical C residues. A region of mtDNA sequence including the 16S and 12S rRNA genes, the D-loop and the cytochrome b gene, may represent the zone of preferred mtDNA mutation in ovarian cancer. The high incidence of mtDNA mutations found in ovarian carcinomas and other human cancers suggests that genetic instability of mtDNA might play a significant role in tumorigenesis.
Starting Page	5998
Ending Page	6001
Page Count	4
File Format	PDF HTM / HTML
PubMed reference number	11507041
Journal	Medline
Volume Number	61
Issue Number	16
Alternate Webpage(s)	http://cancerres.aacrjournals.org/content/canres/61/16/5998.full.pdf?origin=publication_detail
Alternate Webpage(s)	http://cancerres.aacrjournals.org/content/canres/61/16/5998.full.pdf
Alternate Webpage(s)	http://cancerres.aacrjournals.org/content/61/16/5998.full.pdf
Journal	Cancer research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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