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Chapter 5 : Concluding summary and future prospects 5 . 1 Concluding summary
| Content Provider | Semantic Scholar |
|---|---|
| Author | Snyders, Maritza |
| Copyright Year | 2013 |
| Abstract | The background for this study was the importance of glycine N-acyltransferase (EC 2.3.1.13) in detoxification of organic acids that accumulate in the blood and tissues of patients with defects of organic acid metabolism. It is our long term aim to develop a recombinant therapeutic GL YAT enzyme . for the treatment of propionic acidemia and perhaps other organic acidemias. This idea was inspired by a unique individual with propionic acidemia. This person is relatively healthy for a sufferer of propionic acidemia. This is thought to be because of exceptional detoxification of propionic acid, which is demonstrated by the observation that the levels of propionylglycine excreted in the urine of this patient is three orders of magnitude higher than normal (Prof LJ Mienie, personal communication). |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://dspace.nwu.ac.za/bitstream/handle/10394/9622/Badenhorst_CPS_Chapter_5.pdf?isAllowed=y&sequence=6 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Chapter |
