Mutation in the PCSK9 Gene in Omani Arab Subjects with Autosomal Dominant Hypercholesterolemia and its Effect on PCSK9 Protein Structure.

Content Provider	Semantic Scholar
Author	Al-Waili, Khalid A. Al-Zidi, Ward Al-Muna Al-Abri, Abdul Rahim Alrasadi, Khalid Alsabti, Hilal Shah, Karna Al-Futaisi, Abdullah Al-Zakwani, Ibrahim Banerjee, Yajnavalka
Copyright Year	2013
Abstract	Proprotein convertase subtilisin/kexin type (PCSK9) is a crucial protein in LDL cholesterol (LDL-C) metabolism by virtue of its pivotal role in the degradation of the LDL receptor. Mutations in the PCSK9 gene have previously been found to segregate with autosomal dominant familial hypercholesterolemia (ADFH). In this study, DNA sequencing of the 12 exons of the PCSK9 gene has been performed for two patients with a clinical diagnosis of familial hypercholesterolemia where mutation in the LDL-receptor gene hasn't been excluded. One missense mutation was detected in the exon 9 PCSK9 gene in the two ADFH patients. The patients were found to be heterozygote for Ile474Val (SNP rs562556). Using an array of in silico tools, we have investigated the effect of the above mutation on different structural levels of the PCSK9 protein. Although, the mutation has already been reported in the literature for other populations, to the best of our knowledge this is the first report of a mutation in the PCSK9 gene from the Arab population, including the Omani population.
Starting Page	48
Ending Page	52
Page Count	5
File Format	PDF HTM / HTML
DOI	10.5001/omj.2013.11
PubMed reference number	23386946
Journal	Medline
Volume Number	28
Issue Number	1
Alternate Webpage(s)	http://www.omjournal.org/images/334_M_Deatials_Pdf_.pdf
Alternate Webpage(s)	https://doi.org/10.5001/omj.2013.11
Journal	Oman medical journal
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article