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Graft-Versus-Leukemia Effect of Allogeneic Stem-Cell Transplantation and Minimal Residual Disease in Patients With Acute Myeloid Leukemia in First Complete Remission
| Content Provider | Semantic Scholar |
|---|---|
| Author | Versluis, Jurjen Kalin, Burak Zeijlemaker, Wendelien Passweg, Jakob R. Graux, Carlos Manz, Markus G. Vekemans, Marie-Christiane Biemond, Bart J. Legdeur, Marie-Cecile Kooy, Marinus Van Marwijk Weerdt, Okke De Wijermans, Pierre W. Hoogendoorn, Mels Bargetzi, Mario J. Kuball, Jürgen Schouten, H. Velden, Vincent Van Der Janssen, Jeroen J. W. M. Pabst, Thomas Löwenberg, Bob Jongen-Lavrencic, Mojca Schuurhuis, Gerrit J. Ossenkoppele, Gert J. Cornelissen, Jan Jacob |
| Copyright Year | 2017 |
| Abstract | PurposeThe detection of minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) may improve future risk-adapted treatment strategies. We assessed whether MRD-positive and MRD-negative patients with AML benefit differently from the graft-versus-leukemia effect of allogeneic hematopoietic stem-cell transplantation (alloHSCT).MethodsA total of 1,511 patients were treated in subsequent Dutch-Belgian Hemato-Oncology Cooperative Group and the Swiss Group for Clinical Cancer Research AML trials, of whom 547 obtained a first complete remission, received postremission treatment (PRT), and had available flow cytometric MRD before PRT. MRD positivity was defined as more than 0.1% cells with a leukemia-associated immunophenotype within the WBC compartment. PRT consisted of alloHSCT (n = 282), conventional PRT by a third cycle of chemotherapy (n = 160), or autologous hematopoietic stem-cell transplantation (n = 105).ResultsMRD was positive in 129 patients (24%) after induction chemotherapy before ... |
| Starting Page | 1 |
| Ending Page | 13 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| DOI | 10.1200/PO.17.00078 |
| Alternate Webpage(s) | https://clf1.medpagetoday.com/content/pdf/reading-room/asco/JCO-PO.HM.Versluis2017102151512417.pdf |
| Alternate Webpage(s) | https://doi.org/10.1200/PO.17.00078 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
