Catalytic activities of the antitumour complex bis(acetato)bis(imidazole)copper(II) and bis(valproato)bis(imidazole)copper(II) for the oxidation of organic substrates

Content Provider	Semantic Scholar
Author	Abuhijleh, A. Latif
Copyright Year	1996
Abstract	Abstract The catalytic activities of the antitumour complex bis(acetate)bis(imidazole)copper(II) (1)and bis(valproato)bis(imidazole)copper(II) (2) toward the aerobic oxidation of N,N,N′,N′-tetramethyl-p-phenylenediamine (TMPD) to TMPD+ and 3,5-di-t-butylcatechol (DTBC) to 3,5-di-t-butyl-o-benzoquinone were determined. The rates were found to be first order with respect to both substrate and catalyst concentration. Complexes 1 and 2 were found to be effective catalysts for the oxidation cyclization of 0-phenylenediamine (OPD) to 2,3-diaminophenzine, as well as oxidation of hydroquinone to 1,4-benzoquinone. The formation of a copper ion semiquinone species in solution, which may be the catalytic intermediate that reacts directly with oxygen, was demonstrated spectrophotometrically. The results suggested that the oxidation of OPD and DTBC takes place in two one-electron transfer steps. The copper(II) complex/OPD/PPh3 catalyst system was found to catalyse the oxidation of triphenylphosphine (PPh3) to Ph3PO by molecular oxygen. The relevance of these copper(II) complexes to the biological functions of copper-containing proteins are discussed.
Starting Page	285
Ending Page	293
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1016/0277-5387(95)00187-W
Volume Number	15
Alternate Webpage(s)	https://fada.birzeit.edu/bitstream/20.500.11889/3971/1/copper%20acetate-valproate.pdf
Alternate Webpage(s)	https://doi.org/10.1016/0277-5387%2895%2900187-W
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article