NDLI: Niveles de GRP 78 , distribución regional del tejido adiposo y cáncer endometrial

Content Provider	Semantic Scholar
Author	Ciortea, Răzvan Măluţan, Andrei Mihai Angheluta, Lenuta Maria
Copyright Year	2017
Abstract	Background: The association of obesity with endometrial cancer is supported by the presence of endoplasmic reticulum (ER) stress in the adipocyte. Glucose-regulated protein 78 (GRP78) is a marker for ER stress. This protein is a central regulator of ER stress due to its major anti-apoptotic role. It plays an important role in tumor development, progression and chemoresistance. Aim: To look for an association between android and gynoid obesity, plasma GRP78 levels and endometrial cancer. Material and methods: Forty four patients with endometrial cancer aged 72 ± 6 years and 44 healthy women aged 55 ± 9 years were studied. Android and gynoid fat distribution were determined by dual X-ray absorptiometry and plasma GRP78 levels were measured. Results: GRP78 plasma levels were significantly higher in patients with endometrial cancer as compared to the control group. Android fat distribution had a positive correlation with plasma GRP78 levels (p<0.01). Gynoid fat had a negative correlation with plasma GRP78 levels (p<0.01). Conclusions: GRP78 levels are associated with the distribution of adipose tissue and are higher in patients with endometrial cancer. (Rev Med Chile 2016; 144: 1577-1583)
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.scielo.cl/pdf/rmc/v144n12/art09.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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